Targeted calretinin expression in granule cells of calretinin-null mice restores normal cerebellar functions.

@article{Bearzatto2006TargetedCE,
  title={Targeted calretinin expression in granule cells of calretinin-null mice restores normal cerebellar functions.},
  author={Bertrand Bearzatto and Laurent Servais and C{\'e}line Roussel and David Gall and Fawzia Baba-A{\"i}ssa and St{\'e}phane Schurmans and Alban de Kerchove d'Exaerde and Guy Cheron and Serge N Schiffmann},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2006},
  volume={20 2},
  pages={380-2}
}
Ca2 binding proteins such as calretinin, characterized by the presence of EF-hand motifs that bind Ca2+ ions, are involved in the shaping of intraneuronal Ca2+ fluxes. In the cerebellar cortex, information processing tightly relies on variations in intracellular Ca2+ concentration in Purkinje and granule cells. Calretinin-deficient (Cr-/-) mice present motor discoordination, suggesting cellular and network cerebellar dysfunctions. To determine the cell specificity of these alterations, we… CONTINUE READING
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