Targeted axonal import (TAxI) peptide delivers functional proteins into spinal cord motor neurons after peripheral administration.

@article{Sellers2016TargetedAI,
  title={Targeted axonal import (TAxI) peptide delivers functional proteins into spinal cord motor neurons after peripheral administration.},
  author={Drew L Sellers and J. M. G. van Bergen and Russell N. Johnson and Heidi Back and John Ravits and Philip J. Horner and Suzie H Pun},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2016},
  volume={113 9},
  pages={2514-9}
}
A significant unmet need in treating neurodegenerative disease is effective methods for delivery of biologic drugs, such as peptides, proteins, or nucleic acids into the central nervous system (CNS). To date, there are no operative technologies for the delivery of macromolecular drugs to the CNS via peripheral administration routes. Using an in vivo phage… CONTINUE READING