Targeted anti-mitotic therapies: can we improve on tubulin agents?

Abstract

The advent of molecularly targeted drug discovery has facilitated the identification of a new generation of anti-mitotic therapies that target proteins with specific functions in mitosis. The exquisite selectivity for mitosis and the distinct ways in which these new agents interfere with mitosis provides the potential to not only overcome certain… (More)
DOI: 10.1038/nrc2049

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