Targeted and restricted complement activation on acrosome-reacted spermatozoa.

  title={Targeted and restricted complement activation on acrosome-reacted spermatozoa.},
  author={Rebecca C Riley-Vargas and Susan E. Lanzendorf and John P Atkinson},
  journal={The Journal of clinical investigation},
  volume={115 5},
A specific hypoglycosylated isoform of the complement regulator membrane cofactor protein (MCP; CD46) is expressed on the inner acrosomal membrane (IAM) of spermatozoa. This membrane is exposed after the acrosome reaction, an exocytosis event that occurs upon contact with the zona pellucida. We initiated this investigation to assess MCP's regulatory function in situ on spermatozoa. Upon exposure of human spermatozoa to autologous serum or follicular fluid, we unexpectedly observed that acrosome… CONTINUE READING
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