Targeted and nontargeted liposomes for in vivo transfer to rat liver cells of a plasmid containing the preproinsulin I gene.

Abstract

A plasmid containing the rat preproinsulin I gene was entrapped in large liposomes and intravenously administered to rats. Four hours after inoculation, the livers were processed for the isolation of hepatocytes. Kupffer cells, and endothelial cells, DNA was purified, and the exogenous DNA was detected in the different cell DNA preparations by Southern… (More)

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@article{Soriano1983TargetedAN, title={Targeted and nontargeted liposomes for in vivo transfer to rat liver cells of a plasmid containing the preproinsulin I gene.}, author={Philippe Soriano and Janny Dijkstra and Alain Legrand and Halbe H. Spanjer and Danielle Londos-Gagliardi and Frits H. Roerdink and G L Scherphof and Claude Nicolau}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1983}, volume={80 23}, pages={7128-31} }