Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells

@inproceedings{Ball2009TargetedAG,
  title={Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells},
  author={Madeleine Price Ball and Jin Billy Li and Yuan Gao and Je-Hyuk Lee and Emily M. LeProust and In-Hyun Park and Bin Xie and George Q. Daley and George M. Church},
  year={2009}
}
Studies of epigenetic modifications would benefit from improved methods for high-throughput methylation profiling. We introduce two complementary approaches that use next-generation sequencing technology to detect cytosine methylation. In the first method, we designed B10,000 bisulfite padlock probes to profile B7,000 CpG locations distributed over the… CONTINUE READING