Targeted activation of PKA and Epac promotes glioblastoma regression in vitro.

@article{Sugimoto2013TargetedAO,
  title={Targeted activation of PKA and Epac promotes glioblastoma regression in vitro.},
  author={Naotoshi Sugimoto and Shinji Miwa and Hiroyuki Tsuchiya and Yoshiaki H. Hitomi and Hiroyuki Nakamura and Akihiro Yachie and Shoichi Koizumi},
  journal={Molecular and clinical oncology},
  year={2013},
  volume={1 2},
  pages={
          281-285
        }
}
Ras-p44/42 mitogen-activated protein kinase (MAPK) and Akt signaling are the key pathways involved in the promotion of glioblastoma formation. Notably, phosphodiesterase 4 (PDE4) is widely expressed in brain tumors and promotes their growth. PDE4 inhibitors have been reported to suppress glioblastoma growth in vitro and in vivo. The mechanisms underlying these actions, however, have yet to be elucidated. The aim of this study was to investigate whether intracellular cyclic adenosine… CONTINUE READING

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