Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction.

  title={Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction.},
  author={Sawako Tatsumi and Kiyoaki Ishii and Norio Amizuka and Minqi Li and Toshihiro Kobayashi and Kenji Kohno and Masako Ito and Sunao Takeshita and Kyoji Ikeda},
  journal={Cell metabolism},
  volume={5 6},
Bone remodeling is performed by osteoclasts and osteoblasts at the bone surface. Inside of bone is a network of numerous osteocytes, whose specific function has remained an enigma. Here we describe a transgenic mouse model in which inducible and specific ablation of osteocytes is achieved in vivo through targeted expression of diphtheria toxin (DT) receptor. Following a single injection of DT, approximately 70%-80% of the osteocytes, but apparently no osteoblasts, were killed. Osteocyte-ablated… CONTINUE READING