Targeted Therapies in CLL: Monotherapy Versus Combination Approaches

  title={Targeted Therapies in CLL: Monotherapy Versus Combination Approaches},
  author={M. Khan and T. Siddiqi},
  journal={Current Hematologic Malignancy Reports},
  • M. Khan, T. Siddiqi
  • Published 2018
  • Medicine
  • Current Hematologic Malignancy Reports
  • Purpose of ReviewWhile chemoimmunotherapy has improved outcomes in chronic lymphocytic leukemia (CLL), it is not curative, has significant relapse rates, and is not always well tolerated. Recently, novel targeted therapies have been developed to increase response rates and reduce toxicity, especially in high-risk disease. Current goals of CLL therapies are to produce deep and durable, especially minimal residual disease (MRD)-negative, remissions so as to allow patients to ultimately… CONTINUE READING
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