Targeted TET oxidase activity through methyl‐CpG‐binding domain extensively suppresses cancer cell proliferation

@inproceedings{Mizuguchi2016TargetedTO,
  title={Targeted TET oxidase activity through methyl‐CpG‐binding domain extensively suppresses cancer cell proliferation},
  author={Yasuhiko Mizuguchi and Yuriko Saiki and Akira Horii and Shinichi Fukushige},
  booktitle={Cancer medicine},
  year={2016}
}
DNA methyltransferase (DNMT) inhibitors are epigenetic drugs used to treat myelodysplastic syndrome. They not only induce DNA demethylation but also have significant cytostatic and cytotoxic effects; however, the relationships between these characteristics have not been established yet due to the lack of a method to induce only DNA demethylation. Herein, we… CONTINUE READING