Targeted Suppression and Knockout of ASCT2 or LAT1 in Epithelial and Mesenchymal Human Liver Cancer Cells Fail to Inhibit Growth

@article{Bothwell2018TargetedSA,
  title={Targeted Suppression and Knockout of ASCT2 or LAT1 in Epithelial and Mesenchymal Human Liver Cancer Cells Fail to Inhibit Growth},
  author={P. Bothwell and Clare Kron and Evan F Wittke and Bradley N Czerniak and B. P. Bode},
  journal={International Journal of Molecular Sciences},
  year={2018},
  volume={19}
}
  • P. Bothwell, Clare Kron, +2 authors B. P. Bode
  • Published 2018
  • Biology, Medicine
  • International Journal of Molecular Sciences
  • Amino acid transporters alanine-serine-cysteine transporter 2 (ASCT2) and L-Type Amino Acid Transporter 1 (LAT1) are coordinately enhanced in human cancers where among other roles, they are thought to drive mechanistic target-of-rapamycin (mTOR) growth signaling. To assess ASCT2 and LAT1 as therapeutic targets, nine unique short hairpin RNA (shRNA) vectors were used to stably suppress transporter expression in human epithelial (Hep3B) and mesenchymal (SK-Hep1) hepatocellular carcinoma (HCC… CONTINUE READING
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