Targeted Peptide Measurements in Biology and Medicine: Best Practices for Mass Spectrometry-based Assay Development Using a Fit-for-Purpose Approach*

@inproceedings{Carr2014TargetedPM,
  title={Targeted Peptide Measurements in Biology and Medicine: Best Practices for Mass Spectrometry-based Assay Development Using a Fit-for-Purpose Approach*},
  author={Steven A. Carr and Susan E. Abbatiello and Bradley L. Ackermann and Christoph H. Borchers and Bruno Domon and Eric W. Deutsch and Russell P. Grant and Andrew N Hoofnagle and Ruth H{\"u}ttenhain and John Matthew Koomen and Daniel C. Liebler and Tao Liu and Brendan Maclean and Dr VIJAYA MANI and Elizabeth A Mansfield and Hendrik Neubert and Amanda G. Paulovich and Lukas Reiter and Olga Vitek and Ruedi Aebersold and Leigh A Anderson and Robert Bethem and Josip Blonder and Emily S. Boja and Julianne Cook Botelho and Michael T. Boyne and Ralph A. Bradshaw and Alma L. Burlingame and Daniel Wai-Tin Chan and Hasmik Keshishian and Eric W Kuhn and Christopher R. Kinsinger and Jerry S.H. Lee and Soo-Youn Lee and Robert L. Moritz and Juan A Oses-Prieto and N M El Rifai and James Carl Ritchie and Henry Rodriguez and Pothur R. Srinivas and R. Reid Townsend and Jennifer E. van Eyk and Gordon R. Whiteley and Arun P Wiita and Susan T. Weintraub},
  booktitle={Molecular & cellular proteomics : MCP},
  year={2014}
}
Adoption of targeted mass spectrometry (MS) approaches such as multiple reaction monitoring (MRM) to study biological and biomedical questions is well underway in the proteomics community. Successful application depends on the ability to generate reliable assays that uniquely and confidently identify target peptides in a sample. Unfortunately, there is a wide range of criteria being applied to say that an assay has been successfully developed. There is no consensus on what criteria are… CONTINUE READING
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