Targeted Overactivity of β Cell KATP Channels Induces Profound Neonatal Diabetes
@article{Koster2000TargetedOO, title={Targeted Overactivity of $\beta$ Cell KATP Channels Induces Profound Neonatal Diabetes}, author={Jc. Koster and Barbara Marshall and Nancy J. Ensor and John A. Corbett and Cg. Nichols}, journal={Cell}, year={2000}, volume={100}, pages={645-654} }
241 Citations
Expression of ATP-Insensitive KATP Channels in Pancreatic β-Cells Underlies a Spectrum of Diabetic Phenotypes
- Biology, MedicineDiabetes
- 2006
It is demonstrated that a range of phenotypes can be expected for a reduction in ATP sensitivity of β-cell KATP channels and provide models for the corollary neonatal diabetes in humans.
Hyperinsulinism induced by targeted suppression of beta cell KATP channels
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 2002
The results suggest that incomplete suppression of KATP channel activity can give rise to a maintained hyperinsulinism.
The ABCs of Sulfonylurea Receptors, Islet K ATP Channels and the Control of Insulin Secretion
- Biology, Medicine
- 2002
The proper and timely release of insulin from pancreatic islet beta cells is essential to controlling glucose homeostasis. Any dysfunction in the appropriate insulin secretory response can lead to…
Mouse Models of β-cell KATP Channel Dysfunction.
- Biology, MedicineDrug discovery today. Disease models
- 2013
The role of membrane excitability in pancreatic β-cell glucotoxicity
- Biology, MedicineScientific Reports
- 2019
It is clearly demonstrated here that in vitro, hyperexcitability is detrimental to islets whereas underexcitability is protective in in vivo animal models, directly opposite to the effects observed in vitro.
Pancreatic β-cell KATP channels: Hypoglycaemia and hyperglycaemia
- Biology, MedicineReviews in Endocrine and Metabolic Disorders
- 2010
This review highlights the important role of the β-cell KATP channel in glucose physiology and provides an introduction to some of the other review articles in this special edition of the Reviews in Endocrine and Metabolic Disorders.
ATP-sensitive potassium channels in health and disease
- Biology, Medicine
- 2015
This chapter reviews the current understanding of the pancreatic β-cell KATP channel and highlights recent structural, functional, and clinical advances.
Defects in beta cell Ca2+ signalling, glucose metabolism and insulin secretion in a murine model of KATP channel-induced neonatal diabetes mellitus
- Medicine, BiologyDiabetologia
- 2010
The primary defect in KATP-induced neonatal diabetes mellitus is failure of glucose metabolism to elevate [Ca2+]i, which suppresses insulin secretion and mildly alters islet glucose metabolism, which is secondary to the long-term hyperglycaemia and/or hypoinsulinaemia that result from the absence of glucose-dependent insulin secretion.
ATP-sensitive K+ channel signaling in glucokinase-deficient diabetes.
- Biology, MedicineDiabetes
- 2005
The significant abrogation ofnGK(-/-) and nGK(+/-) phenotypes in the absence of K(ATP) demonstrate that a major factor in glucokinase deficiency is indeed altered K( ATP) signaling, and have implications for understanding and therapy of glucokin enzyme-related diabetes.
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