Targeted O2 delivery by low-p50 hemoglobin: a new basis for hemoglobin-based oxygen carriers.

@article{Winslow2005TargetedOD,
  title={Targeted O2 delivery by low-p50 hemoglobin: a new basis for hemoglobin-based oxygen carriers.},
  author={Robert M. Winslow},
  journal={Artificial cells, blood substitutes, and immobilization biotechnology},
  year={2005},
  volume={33 1},
  pages={1-12}
}
We have proposed new criteria for a successful cell-free, hemoglobin-based O2 carrier. These include increased molecular radius, increased viscosity, increased oncotic pressure, and reduced p50. A new molecule, MalPEG-Hb, formulated at 4.2g/dL in lactated Ringer's solution (MP4), has been produced according to these new criteria. MP4 has a p50 of 5-6 mm Hg, oncotic pressure of 49mm Hg and viscosity of 2.2cPs. After 50% exchange transfusion with MP4, rats survive a 60% controlled hemorrhage in… CONTINUE READING