Targeted O2 delivery by low-P50 hemoglobin: a new basis for O2 therapeutics.

@article{Tsai2003TargetedOD,
  title={Targeted O2 delivery by low-P50 hemoglobin: a new basis for O2 therapeutics.},
  author={Amy G. Tsai and Kim D. Vandegriff and Marcos Intaglietta and Robert M. Winslow},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2003},
  volume={285 4},
  pages={
          H1411-9
        }
}
To assess O2 delivery to tissue by a new surface-modified, polyethylene glycol-conjugated human hemoglobin [MP4; Po2 at 50% saturation of hemoglobin (P50); 5.4 mmHg], we studied microcirculatory hemodynamics and O2 release in golden Syrian hamsters hemodiluted with MP4 or polymerized bovine hemoglobin (PolyBvHb; P50 54.2 mmHg). Comparisons were made with the animals' hemodiluted blood with a non-O2 carrying plasma expander with similar solution properties (Dextran-70). Systemic hemodynamics… CONTINUE READING

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