Targeted Molecular Imaging of Cancer Cells Using MS2-Based (129)Xe NMR.

  title={Targeted Molecular Imaging of Cancer Cells Using MS2-Based (129)Xe NMR.},
  author={Keunhong Jeong and Chawita Netirojjanakul and Henrik K Munch and Jinny Sun and Joel A Finbloom and David E Wemmer and Alexander Pines and Matthew B Francis},
  journal={Bioconjugate chemistry},
  volume={27 8},
We have synthesized targeted, selective, and highly sensitive (129)Xe NMR nanoscale biosensors using a spherical MS2 viral capsid, Cryptophane A molecules, and DNA aptamers. The biosensors showed strong binding specificity toward targeted lymphoma cells (Ramos line). Hyperpolarized (129)Xe NMR signal contrast and hyper-CEST (129)Xe MRI image contrast indicated its promise as highly sensitive hyperpolarized (129)Xe NMR nanoscale biosensor for future applications in cancer detection in vivo. 
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