Targeted Induction of Interferon-λ in Humanized Chimeric Mouse Liver Abrogates Hepatotropic Virus Infection

@inproceedings{Nakagawa2013TargetedIO,
  title={Targeted Induction of Interferon-λ in Humanized Chimeric Mouse Liver Abrogates Hepatotropic Virus Infection},
  author={Shin-ichiro Nakagawa and Yuichi Hirata and Takeshi Kameyama and Yukiko Tokunaga and Yasumasa Nishito and Kazuko Hirabayashi and Junichi Yano and Takahiro Ochiya and Chise Tateno and Yasuhito Tanaka and Masashi Mizokami and Kyoko Tsukiyama-Kohara and Kazuaki Inoue and M. Yoshiba and Akinori Takaoka and Michinori Kohara},
  booktitle={PloS one},
  year={2013}
}
BACKGROUND & AIMS The interferon (IFN) system plays a critical role in innate antiviral response. We presume that targeted induction of IFN in human liver shows robust antiviral effects on hepatitis C virus (HCV) and hepatitis B virus (HBV). METHODS This study used chimeric mice harboring humanized livers and infected with HCV or HBV. This mouse model permitted simultaneous analysis of immune responses by human and mouse hepatocytes in the same liver and exploration of the mechanism of… CONTINUE READING
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