Targeted Inactivation of p12Cdk2ap1, CDK2 Associating Protein 1, Leads to Early Embryonic Lethality

@article{Kim2009TargetedIO,
  title={Targeted Inactivation of p12Cdk2ap1, CDK2 Associating Protein 1, Leads to Early Embryonic Lethality},
  author={Yong geun Kim and Jim J. McBride and Lauren C Kimlin and Eung-Kwon Pae and Amit Deshpande and David Wong},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={1362 - 1370}
}
Targeted disruption of murine Cdk2ap1, an inhibitor of CDK2 function and hence G1/S transition, results in the embryonic lethality with a high penetration rate. Detailed timed pregnancy analysis of embryos showed that the lethality occurred between embryonic day 3.5 pc and 5.5 pc, a period of implantation and early development of implanted embryos. Two homozygous knockout mice that survived to term showed identical craniofacial defect, including a short snout and a round forehead. Examination… CONTINUE READING

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