Targeted Genome Replacement via Homology-directed Repair in Non-dividing Cardiomyocytes

Abstract

Although high-throughput sequencing can elucidate the genetic basis of hereditary cardiomyopathy, direct interventions targeting pathological mutations have not been established. Furthermore, it remains uncertain whether homology-directed repair (HDR) is effective in non-dividing cardiomyocytes. Here, we demonstrate that HDR-mediated genome editing using… (More)
DOI: 10.1038/s41598-017-09716-x

Topics

Cite this paper

@inproceedings{Ishizu2017TargetedGR, title={Targeted Genome Replacement via Homology-directed Repair in Non-dividing Cardiomyocytes}, author={Takamaru Ishizu and Shuichiro Higo and Yuki Masumura and Yasuaki P. Kohama and Mikio Shiba and Tomoaki Higo and Masato Shibamoto and A. Nakagawa and Sachio Morimoto and Seiji Takashima and Shungo Hikoso and Yasushi Sakata}, booktitle={Scientific reports}, year={2017} }