Targeted Gene Disruption by Ectopic Induction of DNA Elimination in Tetrahymena.

Abstract

Tetrahymena is a useful eukaryotic model for biochemistry and molecular cell biology studies. We previously demonstrated that targeted ectopic DNA elimination, also called co-Deletion (coDel), can be induced by the introduction of an internal eliminated sequence (IES)-target DNA chimeric construct. In this study, we demonstrate that coDel occurs at most of… (More)
DOI: 10.1534/genetics.115.178525

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