Targeted Fc2'-3-PE40 chimeric protein abolishes passive cutaneous anaphylaxis in mice.

@article{Fishman2000TargetedFC,
  title={Targeted Fc2'-3-PE40 chimeric protein abolishes passive cutaneous anaphylaxis in mice.},
  author={Allison Fishman and Diana Prus and Ruth Belostotsky and Haya Lorberboum-Galski},
  journal={Clinical and experimental immunology},
  year={2000},
  volume={119 3},
  pages={
          398-403
        }
}
The alarming increase in the incidence of allergic diseases in the past decade has led to a clear call for more effective treatment. Recently, we reported on the construction of a chimeric protein for targeted elimination of cells expressing FcepsilonRI receptors. This chimeric protein, designated Fc2'-3-PE40, is composed of a Fc fragment of mouse IgE attached to a truncated form of Pseudomonas exotoxin. The Fc2'-3-PE40 chimeric protein was found to be highly cytotoxic to mouse mast cell lines… CONTINUE READING
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