Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease

@article{Durbin1996TargetedDO,
  title={Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease},
  author={Joan E Durbin and Ren{\'e}e Hackenmiller and M M Simon and David E. Levy},
  journal={Cell},
  year={1996},
  volume={84},
  pages={443-450}
}
The STAT1 transcription factor is activated in response to many cytokines and growth factors. To study the requirement for STAT1 in vivo, we disrupted the Stat1 gene in embryonic stem (ES) cells and in mice. Stat1(-1-)ES cells were unresponsive to interferon (IFN), but retained responsiveness to leukemia inhibitory factor (LIF) and remained LIF dependent for undifferentiated growth. Stat1(-1-1) animals were born at normal frequencies and displayed no gross developmental defects. However, these… CONTINUE READING
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261 , 1730 – 1733 . and related transducers involves a secondary modification requiring an H 7sensitive kinase

  • D. W. Leaman, S. Pisharody, +5 authors G. M. Stark
  • Proc . Natl . Acad . Sci . USA
  • 1996
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