Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

@article{Huszar1997TargetedDO,
  title={Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice},
  author={Dennis Huszar and Catherine A. Lynch and Victoria Fairchild-Huntress and Judy H. Dunmore and Qing Fang and Lucy R Berkemeier and Wei Gu and Robert A Kesterson and Bruce A Boston and Roger D Cone and Françoise J. Smith and L.Arthur Campfield and P James Burn and Frank C. Lee},
  journal={Cell},
  year={1997},
  volume={88},
  pages={131-141}
}
The melanocortin-4 receptor (MC4-R) is a G protein-coupled, seven-transmembrane receptor expressed in the brain. Inactivation of this receptor by gene targeting results in mice that develop a maturity onset obesity syndrome associated with hyperphagia, hyperinsulinemia, and hyperglycemia. This syndrome recapitulates several of the characteristic features of the agouti obesity syndrome, which results from ectopic expression of agouti protein, a pigmentation factor normally expressed in the skin… CONTINUE READING
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