Targeted Delivery to Neuroblastoma of Novel siRNA-anti-GD2-liposomes Prepared by Dual Asymmetric Centrifugation and Sterol-Based Post-Insertion Method

@article{Adrian2011TargetedDT,
  title={Targeted Delivery to Neuroblastoma of Novel siRNA-anti-GD2-liposomes Prepared by Dual Asymmetric Centrifugation and Sterol-Based Post-Insertion Method},
  author={Joanna E. Adrian and A. Wolf and Annette Steinbach and J. R{\"o}ssler and R. Süss},
  journal={Pharmaceutical Research},
  year={2011},
  volume={28},
  pages={2261-2272}
}
  • Joanna E. Adrian, A. Wolf, +2 authors R. Süss
  • Published 2011
  • Chemistry, Medicine
  • Pharmaceutical Research
  • ABSTRACTPurposeTo optimise and simplify preparation of targeted liposomes for efficient siRNA delivery to neuroblastoma, the most common solid tumour in early childhood.MethodsLiposomes containing siRNA were prepared by combining the novel dual asymmetric centrifugation (DAC) method and the recently optimised sterol-based post-insertion technique (SPIT) to couple anti-GD2 antibody for selective interaction with neuroblastoma cells. Cultured human neuroblastoma cell lines were used to evaluate… CONTINUE READING
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    References

    SHOWING 1-10 OF 26 REFERENCES
    Preparation of small amounts of sterile siRNA-liposomes with high entrapping efficiency by dual asymmetric centrifugation (DAC).
    • 49
    • Highly Influential
    Receptor-Specific Targeting with Liposomes In Vitro Based on Sterol-PEG1300 Anchors
    • 28
    Targeted SAINT-O-Somes for improved intracellular delivery of siRNA and cytotoxic drugs into endothelial cells.
    • 35
    • PDF
    RNAi-mediated gene silencing in non-human primates
    • 1,220
    Dual asymmetric centrifugation (DAC)--a new technique for liposome preparation.
    • U. Massing, S. Cicko, V. Ziroli
    • Chemistry, Medicine
    • Journal of controlled release : official journal of the Controlled Release Society
    • 2008
    • 88
    Prospects of RNA interference therapy for cancer
    • 302
    • PDF