Targeted Delivery to Neuroblastoma of Novel siRNA-anti-GD2-liposomes Prepared by Dual Asymmetric Centrifugation and Sterol-Based Post-Insertion Method

@article{Adrian2011TargetedDT,
  title={Targeted Delivery to Neuroblastoma of Novel siRNA-anti-GD2-liposomes Prepared by Dual Asymmetric Centrifugation and Sterol-Based Post-Insertion Method},
  author={Joanna E. Adrian and Alexander Wolf and Annette Steinbach and Jochen R{\"o}ssler and Regine Süss},
  journal={Pharmaceutical Research},
  year={2011},
  volume={28},
  pages={2261-2272}
}
ABSTRACTPurposeTo optimise and simplify preparation of targeted liposomes for efficient siRNA delivery to neuroblastoma, the most common solid tumour in early childhood.MethodsLiposomes containing siRNA were prepared by combining the novel dual asymmetric centrifugation (DAC) method and the recently optimised sterol-based post-insertion technique (SPIT) to couple anti-GD2 antibody for selective interaction with neuroblastoma cells. Cultured human neuroblastoma cell lines were used to evaluate… CONTINUE READING

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