Targeted Delivery of Prostaglandin E1 to Hepatocytes Using Galactosylated Liposomes

@article{Kawakami2000TargetedDO,
  title={Targeted Delivery of Prostaglandin E1 to Hepatocytes Using Galactosylated Liposomes},
  author={Shigeru Kawakami and Chie Munakata and Shintaro Fumoto and Fumiyoshi Yamashita and Mitsuru Hashida},
  journal={Journal of Drug Targeting},
  year={2000},
  volume={8},
  pages={137 - 142}
}
Abstract Prostaglandin E1 (PGE1) was incorporated in galactosylated liposomes containing cholesten-5-yloxy-N-(4-((1-imino-2-β-D-thiogalactosylethyl)amino)butyl)formamide (Gal-C4-Chol) intended for hepatocyte-selective delivery. Liposomes composed of distearoylphosphatidylcholine (DSPC)/cholesterol (Chol)/Gal-C4-Chol (60:35:5) were prepared and compared with DSPC/Chol (60:40) liposomes. After intravenous injection of [3H]-labeled PGE1 or cholesteryl hexadecyl ether (CHE) with the liposomal… 
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