Targeted Deletion of Neuropeptide Y (NPY) Modulates Experimental Colitis

@article{Chandrasekharan2008TargetedDO,
  title={Targeted Deletion of Neuropeptide Y (NPY) Modulates Experimental Colitis},
  author={Bindu P Chandrasekharan and Vanitha Bala and Vasantha L. Kolachala and Matam Vijay-Kumar and Dean Jones and Andrew T. Gewirtz and Shanthi V. Sitaraman and S. Deepak Srinivasan},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={1683 - 1699}
}
BACKGROUND Neurogenic inflammation plays a major role in the pathogenesis of inflammatory bowel disease (IBD). We examined the role of neuropeptide Y (NPY) and neuronal nitric oxide synthase (nNOS) in modulating colitis. METHODS Colitis was induced by administration of dextran sodium sulphate (3% DSS) or streptomycin pre-treated Salmonella typhimurium (S.T.) in wild type (WT) and NPY (NPY(-/-)) knockout mice. Colitis was assessed by clinical score, histological score and myeloperoxidase… CONTINUE READING

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