Targeted Deletion of Fibrinogen Like Protein 1 Reveals a Novel Role in Energy Substrate Utilization

@inproceedings{Demchev2013TargetedDO,
  title={Targeted Deletion of Fibrinogen Like Protein 1 Reveals a Novel Role in Energy Substrate Utilization},
  author={Valeriy Demchev and Geraldine E. Malana and Divya Vangala and Janis M. Stoll and Anal Desai and Hye Won Kang and Yingxia Li and Hamed Nayeb-Hashemi and Michele W Niepel and David M. Cohen and Chinweike Ukomadu},
  booktitle={PloS one},
  year={2013}
}
Fibrinogen like protein 1(Fgl1) is a secreted protein with mitogenic activity on primary hepatocytes. Fgl1 is expressed in the liver and its expression is enhanced following acute liver injury. In animals with acute liver failure, administration of recombinant Fgl1 results in decreased mortality supporting the notion that Fgl1 stimulates hepatocyte proliferation and/or protects hepatocytes from injury. However, because Fgl1 is secreted and detected in the plasma, it is possible that the role of… CONTINUE READING