Targeted Deficiency of the Transcriptional Activator Hnf1α Alters Subnuclear Positioning of Its Genomic Targets

@article{Luco2008TargetedDO,
  title={Targeted Deficiency of the Transcriptional Activator Hnf1α Alters Subnuclear Positioning of Its Genomic Targets},
  author={Reini F. Luco and Miguel Angel Maestro and Nicolas Sadoni and Daniele Zink and Jorge Ferrer},
  journal={PLoS Genetics},
  year={2008},
  volume={4},
  pages={247 - 257}
}
DNA binding transcriptional activators play a central role in gene-selective regulation. In part, this is mediated by targeting local covalent modifications of histone tails. Transcriptional regulation has also been associated with the positioning of genes within the nucleus. We have now examined the role of a transcriptional activator in regulating the positioning of target genes. This was carried out with primary beta-cells and hepatocytes freshly isolated from mice lacking Hnf1alpha, an… CONTINUE READING

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