Targeted Amino Acid Substitutions Impair Streptolysin O Toxicity and Group A Streptococcus Virulence

Abstract

UNLABELLED Streptolysin O is a potent pore-forming toxin produced by group A Streptococcus. The aims of the present study were to dissect the relative contributions of different structural domains of the protein to hemolytic activity, to obtain a detoxified form of streptolysin O amenable to human vaccine formulation, and to investigate the role of… (More)
DOI: 10.1128/mBio.00387-12

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Cite this paper

@inproceedings{Chiarot2013TargetedAA, title={Targeted Amino Acid Substitutions Impair Streptolysin O Toxicity and Group A Streptococcus Virulence}, author={Emiliano Chiarot and Cristina Faralla and Nico Chiappini and Giovanna Tuscano and Fabiana Falugi and Gabriella Gambellini and Annarita Taddei and Sabrina Capo and Elena Cartocci and Daniele Veggi and Alessia Corrado and Simona Mangiavacchi and Simona Tavarini and Maria Scarselli and Robert Janulczyk and Guido Grandi and Immaculada Margarit and Giuliano Bensi}, booktitle={mBio}, year={2013} }