Targeted Ablation of miR-21 Decreases Murine Eosinophil Progenitor Cell Growth

Abstract

MiR-21 is one of the most up-regulated miRNAs in multiple allergic diseases associated with eosinophilia and has been shown to positively correlate with eosinophil levels. Herein, we show that miR-21 is up-regulated during IL-5-driven eosinophil differentiation from progenitor cells in vitro. Targeted ablation of miR-21 leads to reduced eosinophil… (More)
DOI: 10.1371/journal.pone.0059397

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@inproceedings{Lu2013TargetedAO, title={Targeted Ablation of miR-21 Decreases Murine Eosinophil Progenitor Cell Growth}, author={Thomas X. Lu and Eun-Jin Lim and Svetlana Itskovich and John A. Besse and Andrew J. Plassard and Melissa K. Mingler and Joelle A. Rothenberg and Patricia C. Fulkerson and Bruce J. Aronow and Marc E Rothenberg}, booktitle={PloS one}, year={2013} }