Targeted, activatable, in vivo fluorescence imaging of prostate-specific membrane antigen (PSMA) positive tumors using the quenched humanized J591 antibody-indocyanine green (ICG) conjugate.

@article{Nakajima2011TargetedAI,
  title={Targeted, activatable, in vivo fluorescence imaging of prostate-specific membrane antigen (PSMA) positive tumors using the quenched humanized J591 antibody-indocyanine green (ICG) conjugate.},
  author={Takahito Nakajima and Makoto Mitsunaga and Neil Harrison Bander and Warren D. W. Heston and Peter L. Choyke and Hisataka Kobayashi},
  journal={Bioconjugate chemistry},
  year={2011},
  volume={22 8},
  pages={1700-5}
}
In patients with prostate cancer, a positive surgical margin is associated with an increased risk of cancer recurrence and poorer outcome, yet margin status cannot be determined during the surgery. An in vivo optical imaging probe that could identify the tumor margins during surgery could result in improved outcomes. The design of such a probe focuses on a highly specific targeting moiety and a near-infrared (NIR) fluorophore that is activated only when bound to the tumor. In this study, we… CONTINUE READING
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