Targetable activating mutations are very frequent in GCB and ABC diffuse large B-cell lymphoma.

@article{Bohers2014TargetableAM,
  title={Targetable activating mutations are very frequent in GCB and ABC diffuse large B-cell lymphoma.},
  author={Elodie Bohers and Sylvain Mareschal and Abdelilah Bouzelfen and Vinciane Marchand and Philippe Ruminy and Catherine Maingonnat and A M{\'e}nard and Pascaline Etancelin and Philippe Bertrand and Sydney Dubois and Marion Alcantara and Christian Bastard and Herv{\'e} Tilly and Fabrice Jardin},
  journal={Genes, chromosomes & cancer},
  year={2014},
  volume={53 2},
  pages={144-53}
}
Diffuse large B cell lymphoma (DLBCL) is an aggressive and heterogeneous malignancy that can be divided in two major subgroups, germinal center B-cell-like (GCB) and activated B-cell-like (ABC). Activating mutations of genes involved in the BCR and NF-κB pathways (CD79A, CD79B, MYD88, and CARD11) or in epigenetic regulation (EZH2) have been recently reported, preferentially in one of the two DLBCL subtypes. We analyzed the mutational status of these five recurrently mutated genes in a cohort of… CONTINUE READING
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