Target specificity of the new fluoroquinolone besifloxacin in Streptococcus pneumoniae, Staphylococcus aureus and Escherichia coli.

@article{Cambau2009TargetSO,
  title={Target specificity of the new fluoroquinolone besifloxacin in Streptococcus pneumoniae, Staphylococcus aureus and Escherichia coli.},
  author={Emmanuelle Cambau and St{\'e}phanie Matrat and X. S. Pan and Romain Roth Dit Bettoni and C{\'e}line Corbel and Alexandra Aubry and Christine A Lascols and Jean-Yves Driot and Linda M. Fisher},
  journal={The Journal of antimicrobial chemotherapy},
  year={2009},
  volume={63 3},
  pages={443-50}
}
OBJECTIVES Besifloxacin is a new fluoroquinolone in development for ocular use. We investigated its mode of action and resistance in two major ocular pathogens, Streptococcus pneumoniae and Staphylococcus aureus, and in the reference species Escherichia coli. METHODS Primary and secondary targets of besifloxacin were evaluated by: (i) mutant selection experiments; (ii) MIC testing of defined topoisomerase mutants; and (iii) inhibition and cleavable complex assays with purified S. pneumoniae… CONTINUE READING
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