Target specificity of immunoglobulin class switch recombination is not determined by nucleotide sequences of S regions.

@article{Kinoshita1998TargetSO,
  title={Target specificity of immunoglobulin class switch recombination is not determined by nucleotide sequences of S regions.},
  author={Kazuo Kinoshita and Junko Tashiro and Satoshi Tomita and C G Lee and T. Honjo},
  journal={Immunity},
  year={1998},
  volume={9 6},
  pages={849-58}
}
We describe a model system for class switch recombination (CSR) using CH12F3-2 cells transfected with a DNA construct containing two S sequences transcribed by different promoters and separated by a viral thymidine kinase (TK) gene. Recombination observed using this system shares key properties with physiological CSR: deletion of DNA between two S regions, requirement for cytokine stimulation, and nonhomologous and no consensus breakpoint sequences. Studies on transfectants with variants of… CONTINUE READING

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