Target-specific gene silencing of layer-by-layer assembled gold-cysteamine/siRNA/PEI/HA nanocomplex.

@article{Lee2011TargetspecificGS,
  title={Target-specific gene silencing of layer-by-layer assembled gold-cysteamine/siRNA/PEI/HA nanocomplex.},
  author={M Lee and Sang-Jun Park and Kitae Park and Ki Su Kim and Hwiwon Lee and Sei Kwang Hahn},
  journal={ACS nano},
  year={2011},
  volume={5 8},
  pages={6138-47}
}
Target-specific intracellular delivery of small interfering RNA (siRNA) is regarded as one of the most important technologies for the development of siRNA therapeutics. In this work, a cysteamine modified gold nanoparticles (AuCM)/siRNA/polyethyleneimine (PEI)/hyaluronic acid (HA) complex was successfully developed using a layer-by-layer method for target-specific intracellular delivery of siRNA by HA receptor mediated endocytosis. Atomic force microscopic and zeta potential analyses confirmed… CONTINUE READING

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