Target-specific expression of presynaptic mossy fiber plasticity.

  title={Target-specific expression of presynaptic mossy fiber plasticity.},
  author={Gianmaria Maccaferri and Katalin T{\'o}th and Chris J McBain},
  volume={279 5355},
Mossy fiber synaptic transmission at hippocampal CA3 pyramidal cells and interneurons was compared in rat brain slices to determine whether mossy terminals are functionally equivalent. Tetanic stimulation of mossy fibers induced long-term potentiation in pyramidal neurons but was either without effect or it induced depression at synapses onto interneurons. Unlike transmission onto pyramidal neurons, transmission onto interneurons was not potentiated after adenosine 3',5'-monophosphate (cAMP… CONTINUE READING
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