Target sequence-specific inhibition of HIV-1 replication by ribozymes directed to tat RNA.

@article{Sun1995TargetSI,
  title={Target sequence-specific inhibition of HIV-1 replication by ribozymes directed to tat RNA.},
  author={L Q Sun and L Wang and W. L. Gerlach and Geoff P. Symonds},
  journal={Nucleic acids research},
  year={1995},
  volume={23 15},
  pages={2909-13}
}
The structural motif formed between a hammerhead ribozyme and its substrate consists of three RNA double helices in which the sequence 5' to the XUY is termed helix I and the sequence 3' to the XUY helix III. Two hammerhead ribozymes targeted to the tat gene of HIV-1SF2 were designed to study target specificity and the potential effect of helix I mismatch on ribozyme efficacy both in vitro and in vivo. The first ribozyme (Rz1) targeted to the 5' splicing region of the tat gene was designed to… CONTINUE READING
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