Target selectivity in mRNA silencing


Despite the excitement and promise of RNA interference in treating neurodegenerative disease, disease gene mRNA might resist mRNA silencing. Conventional siRNA design does not uniformly distinguish a mutant from a wild-type allele. CAG expansions in trinucleotide repeat diseases are unselective targets for small siRNAs. This review will consider recent… (More)
DOI: 10.1038/


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@article{Aronin2006TargetSI, title={Target selectivity in mRNA silencing}, author={Neil Aronin}, journal={Gene Therapy}, year={2006}, volume={13}, pages={509-516} }