Target recognition, RNA methylation activity and transcriptional regulation of the Dictyostelium discoideum Dnmt2-homologue (DnmA)

@inproceedings{Mller2013TargetRR,
  title={Target recognition, RNA methylation activity and transcriptional regulation of the Dictyostelium discoideum Dnmt2-homologue (DnmA)},
  author={Sara M{\"u}ller and Indra M. Windhof and Vladimir Yu. Maximov and Tomasz P Jurkowski and Albert Jeltsch and Konrad U. F{\"o}rstner and Cynthia M. Sharma and Ralph O Gr{\"a}f and Wolfgang Nellen},
  booktitle={Nucleic acids research},
  year={2013}
}
Although the DNA methyltransferase 2 family is highly conserved during evolution and recent reports suggested a dual specificity with stronger activity on transfer RNA (tRNA) than DNA substrates, the biological function is still obscure. We show that the Dictyostelium discoideum Dnmt2-homologue DnmA is an active tRNA methyltransferase that modifies C38 in tRNA(Asp(GUC)) in vitro and in vivo. By an ultraviolet-crosslinking and immunoprecipitation approach, we identified further DnmA targets… CONTINUE READING
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