Target-oriented therapy: Emerging drugs for atopic dermatitis

@article{Lauffer2016TargetorientedTE,
  title={Target-oriented therapy: Emerging drugs for atopic dermatitis},
  author={Felix Lauffer and Johannes Ring},
  journal={Expert Opinion on Emerging Drugs},
  year={2016},
  volume={21},
  pages={81 - 89}
}
  • F. Lauffer, J. Ring
  • Published 2 January 2016
  • Medicine, Biology
  • Expert Opinion on Emerging Drugs
ABSTRACT Introduction: Atopic dermatitis (AD) is a chronic inflammatory skin disease with a life-time prevalence of 10 – 20% in western countries. Patients suffer from stigmatizing eczematous skin lesions, persisting itch and sleep disorders. Starting usually in early childhood the course of AD is heterogeneous. While most frequently AD disappears before adolescence, about 30% of patients show a chronic persisting course. There is an urgent need for new therapeutic options as until now… 
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References

SHOWING 1-10 OF 89 REFERENCES
Guidelines for treatment of atopic eczema (atopic dermatitis) Part II
The existing evidence for treatment of atopic eczema (atopic dermatitis, AE) is evaluated using the national standard Appraisal of Guidelines Research and Evaluation. The consensus process consisted
Immunology of atopic eczema: overcoming the Th1/Th2 paradigm
TLDR
Current understanding of immune as well as barrier abnormalities into the pathogenesis mosaic of AE are pieces together.
Dupilumab treatment in adults with moderate-to-severe atopic dermatitis.
TLDR
Patients treated with dupilumab had marked and rapid improvement in all the evaluated measures of atopic dermatitis disease activity, and side-effect profiles were not dose-limiting.
Treatment of severe refractory adult atopic dermatitis with ustekinumab
TLDR
A 21-year-old Caucasian woman presented in March 2003 with a longstanding history of atopic dermatitis (AD) in addition to allergic contact dermatitis that emerged in response to paraphenylenediamine and had been diagnosed one year earlier.
Targeting IgE in Severe Atopic Dermatitis with a Combination of Immunoadsorption and Omalizumab.
TLDR
An improvement in AD was observed during the treatment period, with aggravation during follow-up, and further research is needed, based on the principle of reducing IgE levels in order to improve clinical symptoms, using a combination anti-IgE treatment approach, adjusted according to IgE Levels.
Cyclosporin in atopic dermatitis: time to relapse and effect of intermittent therapy
TLDR
It is suggested that CyA treatment may improve the long‐term outcome of atopic dermatitis, although most patients initially relapsed a few weeks after CyA was stopped, although all disease parameters showed improvement when these patients were seen 1 year after the study.
Characterization of different courses of atopic dermatitis in adolescent and adult patients
TLDR
The aim of this study was to classify different courses of AD and to correlate these with specific risk factors for severe variants of AD.
A pilot study of an oral phosphodiesterase inhibitor (apremilast) for atopic dermatitis in adults.
TLDR
Gene ontologic analyses comparing baseline with samples during treatment revealed alterations in immune response pathways, especially those related to cyclic adenosine monophosphate–mediated signaling, which support further development of apremilast for treatment of atopic dermatitis.
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