Target-oriented therapy: Emerging drugs for atopic dermatitis

@article{Lauffer2016TargetorientedTE,
  title={Target-oriented therapy: Emerging drugs for atopic dermatitis},
  author={Felix Lauffer and Johannes Ring},
  journal={Expert Opinion on Emerging Drugs},
  year={2016},
  volume={21},
  pages={81 - 89}
}
  • F. Lauffer, J. Ring
  • Published 2 January 2016
  • Medicine, Biology
  • Expert Opinion on Emerging Drugs
ABSTRACT Introduction: Atopic dermatitis (AD) is a chronic inflammatory skin disease with a life-time prevalence of 10 – 20% in western countries. Patients suffer from stigmatizing eczematous skin lesions, persisting itch and sleep disorders. Starting usually in early childhood the course of AD is heterogeneous. While most frequently AD disappears before adolescence, about 30% of patients show a chronic persisting course. There is an urgent need for new therapeutic options as until now… 
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32 Citations

Spotlight on dupilumab in the treatment of atopic dermatitis: design, development, and potential place in therapy
TLDR
Dupilumab is a fully human monoclonal antibody directed against the IL-4 receptor α subunit that is able to block the signaling of bothIL-4 and IL-13 and achieve rapid and significant improvements in adults with moderate-to-severe AD.
Atopic dermatitis : emerging therapies Two identically designed phase III clinical trials
TLDR
Novel topical and systemic therapies for the safe and effective long-term management of AD are greatly needed as well as novel early life approaches to preventing the disease onset.
Dupilumab for the Treatment of Atopic Dermatitis.
Systemic Treatment of Adult Atopic Dermatitis: A Review
TLDR
This review focuses on the use of systemic treatments in adult AD patients analyzing published literature and indicates that standardized international guidelines are lacking, and the treatment approach widely differs among diverse countries.
Current and emerging topical therapies for atopic dermatitis.
Molecular signatures order the potency of topically applied anti‐inflammatory drugs in patients with atopic dermatitis
The etiopathogenesis of atopic dermatitis: barrier disruption, immunological derangement, and pruritus
TLDR
The etiopathogenesis of the disease is summarized and a rationale for choosing the novel targeted therapy that will be available in the future is provided.
The interplay between genetic and environmental factors in the pathogenesis of atopic dermatitis
TLDR
This review summarizes the etiopathogenesis of AD and provides the rationale for selecting a novel targeted therapy, Dupilumab, which has recently been developed for AD treatment.
The IL-4, IL-13 and IL-31 pathways in atopic dermatitis
TLDR
The IL-4, IL-13, and IL-31 inflammatory pathways have been identified as hallmark features in the pathogenesis of the disease, contributing uniquely and synergistically to immune and barrier abnormalities as well as the key symptoms, such as pruritis.
Pathophysiology, Diagnosis, and Management of Infections in Atopic Dermatitis
TLDR
Assessment of recent changes in the understanding of pathophysiology, diagnosis, and management of infections in Atopic dermatitis finds that more targeted therapies and skin probiotics may address inflammation and S. aureus in the prevention of infection in AD.
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References

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TLDR
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TLDR
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TLDR
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TLDR
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