Target-oriented and diversity-oriented organic synthesis in drug discovery.

@article{Schreiber2000TargetorientedAD,
  title={Target-oriented and diversity-oriented organic synthesis in drug discovery.},
  author={S. Schreiber},
  journal={Science},
  year={2000},
  volume={287 5460},
  pages={
          1964-9
        }
}
  • S. Schreiber
  • Published 2000
  • Chemistry, Medicine
  • Science
  • Modern drug discovery often involves screening small molecules for their ability to bind to a preselected protein target. Target-oriented syntheses of these small molecules, individually or as collections (focused libraries), can be planned effectively with retrosynthetic analysis. Drug discovery can also involve screening small molecules for their ability to modulate a biological pathway in cells or organisms, without regard for any particular protein target. This process is likely to benefit… CONTINUE READING
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