Target of rapamycin (TOR) signaling controls epithelial morphogenesis in the vertebrate intestine.

@article{Makky2007TargetOR,
  title={Target of rapamycin (TOR) signaling controls epithelial morphogenesis in the vertebrate intestine.},
  author={Khadijah Makky and Jackie Tekiela and Alan N Mayer},
  journal={Developmental biology},
  year={2007},
  volume={303 2},
  pages={501-13}
}
The target of rapamycin (TOR) signaling pathway regulates cell growth and proliferation, however the extent to which TOR signaling mediates particular organogenesis programs remains to be determined. Here we report an examination of TOR signaling during zebrafish development, using a combination of small molecule treatment and morpholino-mediated gene knockdown. First, we amplified and sequenced the full-length cDNA for the zebrafish TOR ortholog (ztor). By in situ hybridization, we found that… CONTINUE READING

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