Target identification and validation of novel antimalarials.

  title={Target identification and validation of novel antimalarials.},
  author={Case W. McNamara and Elizabeth A. Winzeler},
  journal={Future microbiology},
  volume={6 6},
It has been recognized that new antimalarials with a novel mode of action are critical to combat the continued emergence and dissemination of drug-resistant parasites that threaten the efficacy of current malaria treatments. Thus, recent high-throughput screening campaigns have been initiated using asexual intraerythrocytic stage cell-based assays of Plasmodium falciparum. These have led to the unprecedented identification of over 10,000 new antimalarial compounds. Inherently, novel compounds… CONTINUE READING

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