Target identification and validation of novel antimalarials.

@article{McNamara2011TargetIA,
  title={Target identification and validation of novel antimalarials.},
  author={Case W. McNamara and Elizabeth A. Winzeler},
  journal={Future microbiology},
  year={2011},
  volume={6 6},
  pages={693-704}
}
It has been recognized that new antimalarials with a novel mode of action are critical to combat the continued emergence and dissemination of drug-resistant parasites that threaten the efficacy of current malaria treatments. Thus, recent high-throughput screening campaigns have been initiated using asexual intraerythrocytic stage cell-based assays of Plasmodium falciparum. These have led to the unprecedented identification of over 10,000 new antimalarial compounds. Inherently, novel compounds… CONTINUE READING

2 Figures & Tables

Topics