Target genes and structure of the direct repeats in the DNA-binding sequences of the response regulator PhoP in Streptomyces coelicolor

@inproceedings{SolaLanda2008TargetGA,
  title={Target genes and structure of the direct repeats in the DNA-binding sequences of the response regulator PhoP in Streptomyces coelicolor},
  author={Alberto Sola-Landa and Antonio Rodr{\'i}guez-Garc{\'i}a and Alexander Kristian Apel and Juan F. Martin},
  booktitle={Nucleic acids research},
  year={2008}
}
Expression of genes belonging to the pho regulon in Streptomyces coelicolor is positively regulated (as shown by comparing the wild-type and a DeltaphoP mutant) by binding of the response regulator PhoP to 11-nt direct repeats (DRus). These sequences have been found in over 100 genes of Streptomyces coelicolor; 20 of them were cloned and the binding of PhoP(DBD) to most of their promoters has been shown by electrophoretic mobility shift assays. Deletion experiments showed that at least two DRus… CONTINUE READING

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