Target genes, consensus binding site, and role of phosphorylation for the response regulator MtrA of Corynebacterium glutamicum.

@article{Brocker2011TargetGC,
  title={Target genes, consensus binding site, and role of phosphorylation for the response regulator MtrA of Corynebacterium glutamicum.},
  author={Melanie Brocker and Christina Mack and Michael Bott},
  journal={Journal of bacteriology},
  year={2011},
  volume={193 5},
  pages={
          1237-49
        }
}
The two-component signal transduction system consisting of the sensor kinase MtrB and the response regulator MtrA is highly conserved in corynebacteria and mycobacteria. Whereas mtrA of Mycobacterium tuberculosis was reported to be essential, we recently succeeded in creating ΔmtrAB and ΔmtrA deletion mutants of Corynebacterium glutamicum and provided evidence that mepA and nlpC, both encoding putative cell wall peptidases, are directly repressed by MtrA, whereas proP and betP, both encoding… CONTINUE READING

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