Target-derived BMP signaling limits sensory neuron number and the extent of peripheral innervation in vivo.

@article{Guha2004TargetderivedBS,
  title={Target-derived BMP signaling limits sensory neuron number and the extent of peripheral innervation in vivo.},
  author={Udayan Guha and W. Gomes and Jayshree Samanta and Meenakshi. V. Gupta and Frank L. Rice and John A Kessler},
  journal={Development},
  year={2004},
  volume={131 5},
  pages={1175-86}
}
The role of target-derived BMP signaling in development of sensory ganglia and the sensory innervation of the skin was examined in transgenic animals that overexpress either the BMP inhibitor noggin or BMP4 under the control of a keratin 14 (K14) promoter. Overexpression of noggin resulted in a significant increase in the number of neurons in the trigeminal and dorsal root ganglia. Conversely, overexpression of BMP4 resulted in a significant decrease in the number of dorsal root ganglion… CONTINUE READING
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Bone morphogenetic proteins and their antagonists in skin and hair follicle biology

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