Target deconvolution techniques in modern phenotypic profiling.

@article{Lee2013TargetDT,
  title={Target deconvolution techniques in modern phenotypic profiling.},
  author={Jiyoun Lee and Matthew S Bogyo},
  journal={Current opinion in chemical biology},
  year={2013},
  volume={17 1},
  pages={
          118-26
        }
}
The past decade has seen rapid growth in the use of diverse compound libraries in classical phenotypic screens to identify modulators of a given process. The subsequent process of identifying the molecular targets of active hits, also called 'target deconvolution', is an essential step for understanding compound mechanism of action and for using the identified hits as tools for further dissection of a given biological process. Recent advances in 'omics' technologies, coupled with in silico… CONTINUE READING

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