Target controlled infusions: targeting the effect site while limiting peak plasma concentration

Abstract

Background: Target controlled infusion (TCI) systems are available commercially worldwide, except in North America. Existing systems target the plasma drug concentration, which may be less than ideal because the plasma is not the site of drug effect. The commonly accepted existing algorithm to target the site of drug effect results in high plasma… (More)
DOI: 10.1109/TBME.2004.827935

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Cite this paper

@article{Poucke2004TargetCI, title={Target controlled infusions: targeting the effect site while limiting peak plasma concentration}, author={Guido E. Van Poucke and Louis J. B. Bravo and Steven L. Shafer}, journal={IEEE Transactions on Biomedical Engineering}, year={2004}, volume={51}, pages={1869-1875} }