Target cell-restricted and -enhanced apoptosis induction by a scFv:sTRAIL fusion protein with specificity for the pancarcinoma-associated antigen EGP2.

@article{Bremer2004TargetCA,
  title={Target cell-restricted and -enhanced apoptosis induction by a scFv:sTRAIL fusion protein with specificity for the pancarcinoma-associated antigen EGP2.},
  author={Edwin Bremer and Jos M. A. Kuijlen and Douwe F. Samplonius and Henning Walczak and Lou H. M. F. de Leij and Wijnand Helfrich},
  journal={International journal of cancer},
  year={2004},
  volume={109 2},
  pages={281-90}
}
The apparent tumor selective apoptosis-inducing activity of recombinant soluble TNF-related apoptosis-inducing ligand (TRAIL) has aroused much interest for use in clinical application. However, to exploit fully its therapeutic potential, the characteristics of both the TRAIL receptor system and soluble TRAIL (sTRAIL) should be taken into account: first, the widespread expression of the various TRAIL receptors throughout the human body; second, the differential binding affinities and… CONTINUE READING
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