Target cell polarity and membrane phosphorylation in relation to the mechanism of action of antidiuretic hormone.

@article{Schwartz1974TargetCP,
  title={Target cell polarity and membrane phosphorylation in relation to the mechanism of action of antidiuretic hormone.},
  author={Irving L. Schwartz and Linda J. Shlatz and E Kinne-saffran and Rolf Kinne},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1974},
  volume={71 7},
  pages={2595-9}
}
The plasma membrane of the bovine renal collecting duct epithelial cell has been resolved into its apical (luminal) and basal-lateral (contraluminal) components by free flow electrophoresis. The contraluminal, but not the luminal, membrane was found to contain antidiuretic hormone-sensitive adenylate cyclase. The luminal membrane was found to contain a cyclic 3':5'-adenosine monophosphate-sensitive self-phosphorylating system consisting of a membrane-bound protein kinase and its membrane-bound… CONTINUE READING

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